A team work



1.                   Microwaves inhibit the growth of malaria parasites non-thermally in vitro and in vivo. Lorena M. Coronado, José A. Stoute, Chris T. Nadovich, Jiping Cheng, Ricardo Correa, Kevin Chaw, Guadalupe González, Maytee Zambrano, Rolando A. Gittens, Dinesh K. Agrawal, John K. Smith, William D. Jemison, Carlos A. Donado Morcillo, Carmenza Spadafora. Frontiers in Cellular and Infection Microbiology (Submitted May 2022)

2.                   Evaluation of the in vitro and in vivo anti plasmodial effect of water treated with Photonic Multiphase Modulators (PMM) designed with Advanced Physics System Engineering (APSE™) and BioPhoton-X™ technology. Rosa Coromoto De Jesús, Rocío Izos, Laura Pineda, Julio Lavergne, Victor De Franco Levi, Lorena Coronado, Carmenza Spadafora. Journal of Photochemistry and Photobiology, B: Biology. Volume 223, October 2021, 112283.

3.                   Structure Modification, Antidiatom, Antiplasmodial and Toxic Evaluations of a Series of New Marine-Derived 14-Membered Resorcylic Acid Lactone Derivatives. Wei-Feng Xu, Na-Na Wu, Yan-Wei Wu, Yue-Xuan Qi, Mei-Yan Wei, Laura M. Pineda, Michelle Ng, Carmenza Spadafora, Ji-Yong Zheng, Ling Lu, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao. Marine Life Science & Technology (2021), 1-10. 10.1007/s42995-021-00103-0

4.                   Bufadienolides from the skin secretions of the Neotropical toad Rhinella alata (Anura: Bufonidae): antiprotozoal activity against Trypanosoma cruzi. Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle NG, Carmenza Spadafora, Armando A. Durant-Archibold, Marcelino Gutiérrez. (2021) Molecules, 26 (14), 4217.

5.                   Semisynthesis, antiplasmodial activity, and mechanism of action studies of isocoumarin derivatives. Lorena Coronado, Xue-Qing Zhang, Doriana Dorta, Nerea Escala, Laura Pineda, Michelle Ng, Esther Del Olmo, Chang-Yun Wang, Yu-Cheng Gu, Chang-Lun Shao, Carmenza Spadafora. Journal of Natural Products May 21, (2021) 84, 5, 1434–1441.

6.                   19-hydroxy-bufalin, a major bufadienolide isolated from the parotoid gland secretions of the Panamanian endemic toad Rhinella centralis (Bufonidae), inhibits the growth of Trypanosoma cruzi. Candelario Rodriguez, Armando Durant, Roberto Ibañez, Michelle Ng, Carmenza Spadafora, Marcelino Gutierrez. Toxicon 177 (2020) 89–92. doi: 10.1016/j.toxicon.2020.02.009

7.                   Antiplasmodial activity from leaves of Cocos nucifera in Plasmodium berghei infected mice. Nicole M. Tayler, Rosa De Jesús de Durán, Rita Spadafora, Lorena M. Coronado, Carmenza Spadafora. J Parasit Dis 44, 305–313 (2020).

8.                   Extracellular vesicles could carry an evolutionary footprint in interkingdom communication. Ricardo Correa, Zuleima Caballero, Luis Fernando De León and Carmenza Spadafora. Front Cell Infect Microbiol. 2020 Mar 3;10:76. doi: 10.3389/fcimb.2020.00076. eCollection 2020 

9.                Access and Benefit Sharing under the Nagoya Protocol – Quo vadis? Six Latin American case studies assessing opportunities and risk. Michael Heinrich, Francesca Scotti, Adolfo Andrade-Cetto, Monica Berger-Gonzalez, Javier Echeverría, Fabio Friso, Felipe Garcia-Cardona, Alan Hesketh, Martin Hitziger, Caroline Maake, Matteo Politi, Carmenza Spadafora and Rita Spadafora. Frontiers in Pharmacology 11, 765, 2020.

10.                Thermo-Energetic study in blood Infected with Plasmodium falciparum radiated at 2.45 GHz. Ngo, K. D.; Plazaola, C.; González, G; Spadafora, C.; Zambrano, M.  EuMC 2019 pp. 276-279. doi:10.23919/EuMC.2019.8910930.

11.                Analysis of the antiparasitic and anticancer activity of the Coconut Palm (Cocos nucifera L. ARECACEAE) from the Natural Reserve of Punta Patiño, Darién. Nicole Tayler Sucre, Cristopher A. Boya, Liuris Herrera, Jamie Moy, Michelle Ng, Laura Pineda, Alejandro Almanza, Sara Rosero, Lorena Coronado, Ricardo Correa, Ricardo Santamaría, Zuleima Caballero, Armando A. Durant-Archibold, Kevin J. Tidgewell, Marcy J. Balunas, William H. Gerwick, Alida Spadafora, Marcelino Gutiérrez, Carmenza Spadafora. PLOS ONE 2019 Apr 2;14(4):e0214193. doi: 10.1371/journal.pone.0214193. eCollection 2019.

13.                Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro. Ricardo Correa M, Lorena M Coronado, Zuleima Caballero, Paula Faral, Carlos Robello and Carmenza Spadafora. Scientific Reports 2019 Mar 25;9(1):5042. doi: 10.1038/s41598-019-41697-x

14.                Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa. Sergio Martínez-Luis, Lilia Cherigo, Carmenza Spadafora and Marcelino Gutiérrez. Natural Product Communication 14 (1), 31-32. 2019. doi: 10.1177/1934578X1901400109

15.                Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum. Torres-Mendoza D, Coronado LM, Pineda LM, Guzmán HM, Dorrestein PC, Spadafora C, Gutiérrez M. Molecules. 2018 Aug 29;23(9). doi: 10.3390/molecules23092179

16.                Revisión de Modelos Hiperelásticos utilizados en Tejidos. Moreno, Miguel; Plazaola, Carlos;  González, Guadalupe; Zambrano, Mayteé and Spadafora, Carmenza (2018). KnE Engineering. 3 (1), 100-110. doi: 10.18502/keg.v3i1.1417

17.                Bastimolide B, An Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. Chang-Lun Shao; Xiao-Feng Mou; Fei Cao; Carmenza Spadafora; Evgenia Glukhov; Lena Gerwick; Chang-Yun Wang; William Gerwick. J Nat Prod. 2018 81(1):211-215. doi: 10.1021/acs.jnatprod.7b0091e7

18.                Evaluation of malaria pathology development in a group of CB6F1 mice produced in the laboratory animal facilities of INDICASAT AIP. Rosa De Jesús and Carmenza Spadafora. MOJ Bioequiv Availab. 2018;5(5):264-268. DOI: 10.15406/mojbb.2018.05.00112

19.                Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian Mangrove Plants.  Dioxelis Lopez, Carmenza Spadafora, Lilia Cherigo, Alejandro de Sedas, Sergio Martinez. Asian Pacific Journal of Tropical Medicine. 2018, 11(1):32. doi: 10.1186/s13065-019-0540-8

20.                Volatile organic compounds associated with Plasmodium falciparum infection in vitro. Ricardo Correa, Lorena M. Coronado, Anette C. Garrido, Armando A. Durant-Archibold and Carmenza Spadafora. Parasites and Vectors. 2017 May 2;10(1):215. doi: 10.1186/s13071-017-2157-x

21.                Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives. Xue-Qing Zhang, Carmenza Spadafora, Laura M. Pineda, Michelle Ng W., Ji-Hong Sun, Wei Wang, Changyun Wang, Yucheng Gu & Chang-Lun Shao. Scientific Reports 2017 Sep 18;7(1):11822. doi: 10.1038/s41598-017-12336-0

22.                Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. J Nat Prod. 2017, 80(8):2328-2334. doi: 10.1021/acs.jnatprod.7b00367

23.                Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants. Cristopher A. Boya P, Hermógenes Fernández-Marín, Luis C. Mejía, Carmenza Spadafora, Pieter C. Dorrestein and Marcelino Gutiérrez. Scientific Reports. 2017 Jul 17;7(1):5604.  doi: 10.1038/s41598-017-05515-6

24.                Dudalawamides A-D, Antiparasitic cyclic depsipeptides from the marine cyanobacterium Moorea producens. J Almaliti, KL Malloy, E Glukhov, C Spadafora, M Gutiérrez, WH Gerwick. Journal of Natural Products. 2017 Jun 23;80(6):1827-1836. doi: 10.1021/acs.jnatprod.7b00034

25.                Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice. Neil C. Lax, Kh Tanvir Ahmed, Christopher M. Ignatz, Carmenza Spadafora, Benedict J. Kolber, and Kevin Tidgewell. Pharm Biol. 2016 May 14:1-9. doi: 10.1080/13880209.2016.1181659

26.                Blood stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields. Coronado LM, Montealegre S, Chaverra Z, Mojica L, Espinosa C, Almanza A, Correa R, Stoute JA, Gittens RA, Spadafora C. PLoS One. 2016 Aug 18;11(8):e0161207. doi: 10.1371/journal.pone.0161207. eCollection 2016

27.                Medusamida A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids. Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ. Org Lett. 2016 Feb 5;18(3):352-5. doi: 10.1021/acs.orglett.5b03110

28.                Phytochemical composition, antiparasitic and α-glucosidase inhibition activities from Pelliciera rhizophorae. López D, Cherigo L, Spadafora C, Loza-Mejía MA, Martínez-Luis S. Chem Cent J. 2015 Sep 28;9(1):53. doi: 10.1186/s13065-015-0130-3. eCollection 2015

29.                Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. J Org Chem. 2015 Aug 21;80(16):7849-55. doi: 10.1021/acs.joc.5b01264

30.                Malarial hemozoin: from target to tool. Lorena M. Coronado, Christoper T. Nadovich, Carmenza Spadafora. Biochim Biophys Acta General Subjects. 2014 Jun;1840(6):2032-41 doi: 10.1016/j.bbagen.2014.02.009. MALARIA NEXUS TOP TEN MOST POPULAR ARTICLES IN 2014

31.                Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Celso Almeida, Humberto Ortega, Sarah Higginbotham, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Kursar Thomas A, William H. Gerwick and Luis Cubilla-Rios. Letters of Applied Microbiology (2014) 59(1):58-64  doi: 10.1111/lam.12245

32.                Sloth hair as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity. Sarah Higginbotham, Weng Ruh Wong, Roger G. Linington, Carmenza Spadafora, Liliana Iturrado, A. Elizabeth Arnold. PLoS One 2014 Jan 15;9(1):e84549. doi: 10.1371/journal.pone.0084549

33.                Antimalarial activity and metabolic profiling by HS-SPME-GC-MS of Plinia cerrocampanensis leaf essential oil.  Armando A Durant, Candelario Rodriguez, Liuris Herrera, Alejandro Almanza, Ana I Santana, Carmenza Spadafora and Mahabir P Gupta. Malaria J 01/2014; 13(1):18  doi:10.1186/1475-2875-13-18

34.                Microwave Exposure System for In Vitro and In Vivo Studies. Nadovich, C T, W D Jemison, J A Stoute, and C Spadafora. 2014. COMSOL Conference Paper, Boston.

35.                Bioactivity of fungal endophytes as a function of endophyte taxonomy and the taxonomy and distribution of their host plants. Higginbotham SJ, Arnold AE, Ibañez A, Spadafora C, Coley PD, Kursar, TA (2013). PLoS ONE 8(9): e73192. doi:10.1371/journal.pone.0073192

36.                Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama. Sosa N, Capitán Z, Nieto J, Nieto M, Calzada J, Paz H, Spadafora C, Kreishman-Deitrick M, Kopydlowski K, Ullman D, McCarthy WF, Ransom J, Berman J, Scott C, Grogl M. Am J Trop Med Hyg. 2013 Sep;89(3):557-63. doi: 10.4269/ajtmh.12-0736. 

37.                Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means. Coronado, L. M., Tayler, N. M., Correa, R., Giovani, R. M., Spadafora, C. J. Vis. Exp. (73), e50342, doi:10.3791/50342 (2013)

38.                Antitrypanosomal Alkaloids from the marine bacterium Bacillus pumilu. Sergio Martínez-Luis, José Félix Gómez, Carmenza Spadafora, Héctor M. Guzmán, Marcelino Gutiérrez. Molecules, 2012 Sep 18;17(9):11146-55. doi: 10.3390/molecules170911146

39.                Coibacins A-D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. Org Lett. 2012 Aug 3;14(15):3878-3881. doi: 10.1021/ol301607q

40.                Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. Eunice Molinar, Nivia Rios, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios  Tetrahedron Lett. 2012 Feb 20;53(8):919-922. doi: 10.1016/j.tetlet.2011.12.021

41.                Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544.  Martínez-Luis S, Cherigo L, Arnold E, Spadafora C, Gerwick WH, Cubilla-Rios L.  Natural product communications. 02/2012; 7(2):165-8. PMID: 22474943

42.                Evaluation of phytotoxic, cytotoxic and antiparasitic in vitro activities of Borreria verticillata, a weed of Panamanian coffee crops. L Cherigo, J Lezcano, C Spadafora, Sergio Martínez-Luis. Bioscience Research, 2012 9(2):82-86.

43.                Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov. Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH. J Nat Prod. 2012 Jan 27;75(1):60-6. doi: 10.1021/np200611f

44.                Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. Martínez-Luis S, Cherigo L, Higginbotham S, Arnold E, Spadafora C, Ibañez A, Gerwick WH, Cubilla-Rios L. Int Microbiol. 2011 Jun;14(2):95-102. doi: 10.2436/20.1501.01.139

45.                Chemical constituents from the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. Moreno, E., Varughese, T., Spadafora, C., Arnold, AE,  Coley, PD, Kursar, TA, Gerwick, WH and  Cubilla-Rios, L. Natural Product Communications, (2011) Vol. 6(6):835-840. PMCID: PMC3375898

46.                Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes.   Awandare GA, Spadafora C, Moch JK, Dutta S, Haynes JD, Stoute JA. Mol Biochem Parasitol. (2011) 177(1):57-60. doi: 10.1016/j.molbiopara.2011.01.005

47.      Comparison of the in vitro invasive capabilities of Plasmodium falciparum 7G8 schizonts isolated by Percoll gradient or using magnetic based separation. Spadafora, C., Gerena, L. and Kopydlowski, KM. (2011) Malaria Journal 2011, 10:96 . doi: 10.1186/1475-2875-10-96.Featured in Wikipedia.    

48.                Cytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera.  Emily Mevers,Wei-Ting Liu, Niclas Engene, Hosein Mohimani, Tara Byrum, Pavel A. Pevzner, Pieter C. Dorrestein, Carmenza Spadafora, and William H. Gerwick. J Nat Prod. (2011) 74(5):928-36. doi: 10.1021/np200077f

49.                Automated Synchronization of P. falciparum using a Temperature Cycling Incubator (TCI). Almanza, A., Coronado, L., Tayler, N., Herrera, L. and Spadafora, C. Curr Trends Biotech Pharmacol (2011) Vol 5 (2):1130-133

50.                Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum. Spadafora, C., Awandare, G., Kopydlowski, K., Czege, J,, Moch, JK., Finberg, RW, Tsokos, G., Stoute, JA. (2010) PLoS Pathog Jun 17;6(6):e1000968. doi: 10.1371/journal.ppat.1000968

51.                In vitro and in vivo experimental models in drug screening and development for Chagas disease.  Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C,, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A.. Memórias do Instituto Oswaldo Cruz (2010) 105(2): 233-238. doi: 10.1590/s0074-02762010000200022

52.                Additional anti-leishmanial constituents of the Panamanian Endophytic fungus Edenia sp.  Martínez-Luis S; Cherigo, L; Spadafora, C;, Gerwick, WH.; and Cubillas-Rios, L   Rev. Latinoamer. Quím. (2009)   37(2), 104-114.

53.                Two Casein Kinase 1 isoforms are differentially expressed in the protozoan parasite Trypanosoma cruzi.  Spadafora, C., Repetto, Y., Torres, C., Pino, L., Robello, C., Espinoza, I., Galanti, N., Morello, A., Gamarro, F., and Castanys, S. Molecular and Biochemical Parasitology (2002) 124/1-2:23-36. doi: 10.1016/s0166-6851(02)00156-1