Publications

A team work

  1. Antiplasmodial activity from leaves of Cocos nucifera in Plasmodium berghei infected mice. Nicole M. Tayler, Rosa De Jesús de Durán, Rita Spadafora, Lorena M. Coronado, Carmenza Spadafora. Tropical Biomedicine (Submitted)
  2. Diversity of endophytic fungi associated with Panamanian mangrove plants and evaluation of their antiparasitic, anticancer, and hypoglycemic activities. Dioxelis Lopez, Luis C. Mejia, Michelle Flores, Lilia Cherigo, Carmenza Spadafora, Sergio I. Martinez-Luis. BMC Biotechology (Submitted)
  3. Plasmodium berghei infected mice.Use of QBC F.A.S.T.TM Malaria Stain to quantify Plasmodium falciparum parasitemias by flow cytometry. Coronado L, Ramos M, Spadafora C. Curr Trends Biotech Pharm (Accepted)
  4. Thermo-Energetic study in blood Infected with Plasmodium falciparum radiated at 2.45 GHz. Ngo, K. D.; Plazaola, C.; González, G; Spadafora, C.; Zambrano, M.   Paper at EuMC 2019 (European Microwave Conference), Paris, France.
  5. Analysis of the antiparasitic and anticancer activity of the Coconut Palm (Cocos nucifera ARECACEAE) from the Natural Reserve of Punta Patiño, Darién. Nicole Tayler Sucre, Cristopher A. Boya, Liuris Herrera, Jamie Moy, Michelle Ng, Laura Pineda, Alejandro Almanza, Sara Rosero, Lorena Coronado, Ricardo Correa, Ricardo Santamaría, Zuleima Caballero, Armando A. Durant-Archibold, Kevin J. Tidgewell, Marcy J. Balunas, William H. Gerwick, Alida Spadafora, Marcelino Gutiérrez, Carmenza Spadafora. PLOS ONE 2019 Apr 2;14(4):e0214193
  6. Apparatus for the treatment of Malaria. Patent application number (UK) GB1902634.3 Filing date: Feb 27, 2019. Spadafora C. and Penn State University.
  7. Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparum in vitro. Ricardo Correa M, Lorena M Coronado, Zuleima Caballero, Paula Faral, Carlos Robello and Carmenza Spadafora. Scientific Reports9, Article number: 5042 (2019)
  8. Antiparasitic Compounds from the Panamanian Marine Bacterium Pseudomonas aeruginosa. Sergio Martínez-Luis, Lilia Cherigo, Carmenza Spadafora and Marcelino Gutiérrez. Natural Product Communication 14 (1), 31-32. 2019.
  9. Pumilacidins from the Octocoral-Associated Bacillus DT001 Display Anti-Proliferative Effects in Plasmodium falciparum. Torres-Mendoza D, Coronado LM, Pineda LM, Guzmán HM, Dorrestein PC, Spadafora C, Gutiérrez M. Molecules. 2018 Aug 29;23(9).
  10. Revisión de Modelos Hiperelásticos utilizados en Tejidos. Moreno, Miguel; Plazaola, Carlos; González, Guadalupe; Zambrano, Mayteé and Spadafora, Carmenza (2018). KnE Engineering. 3. 100. 10.18502/keg.v3i1.1417.
  11. Bastimolide B, An Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group. Chang-Lun Shao; Xiao-Feng Mou; Fei Cao; Carmenza Spadafora; Evgenia Glukhov; Lena Gerwick; Chang-Yun Wang; William Gerwick. J Nat Prod. 2018 81(1):211-215.
  12. Evaluation of antiparasitic, anticancer, antimicrobial and hypoglycemic properties of organic extracts from Panamanian Mangrove Plants. Dioxelis Lopez, Carmenza Spadafora, Lilia Cherigo, Alejandro de Sedas, Sergio Martinez. Asian Pacific Journal of Tropical Medicine. 2018, 11(1):32.
  13. Discovery, Semisynthesis, Antiparasitic and Cytotoxic Evaluation of 14-Membered Resorcylic Acid Lactones and Their Derivatives. Xue-Qing Zhang, Carmenza Spadafora, Laura M. Pineda, Michelle Ng W., Ji-Hong Sun, Wei Wang, Changyun Wang, Yucheng Gu. Scientific Reports 2017 Sep 18;7(1):11822
  14. Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species. Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH. J Nat Prod. 2017, 80(8):2328-2334.
  15. Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants. Cristopher A. Boya P, Hermógenes Fernández-Marín, Luis C. Mejía, Carmenza Spadafora, Pieter C. Dorrestein and Marcelino Gutiérre Scientific Reports. 2017 Jul 17;7(1):5604
  16. Dudalawamides A-D, Antiparasitic clyclic depsipeptides from the marine cyanobacterium Moorea producens. J Almaliti, KL Malloy, E Glukhov, C Spadafora, M Gutiérrez, WH Gerwick. Journal of Natural Products. 2017 Jun 23;80(6):1827-1836
  17. Volatile organic compounds associated with Plasmodium falciparum infection in vitro. Ricardo Correa, Lorena M. Coronado, Anette C. Garrido, Armando A. Durant-Archibold and Carmenza Spadafora. Parasites and Vectors. 2017 May 2;10(1):215.
  18. Marine cyanobacteria-derived serotonin receptor 2C active fraction induces psychoactive behavioral effects in mice. Neil C. Lax, Kh Tanvir Ahmed, Christopher M. Ignatz, Carmenza Spadafora, Benedict J. Kolber, and Kevin Tidgewell. Pharm Biol. 2016 May 14:1-9
  19. Blood stage Plasmodium falciparum Exhibits Biological Responses to Direct Current Electric Fields. Coronado LM, Montealegre S, Chaverra Z, Mojica L, Espinosa C, Almanza A, Correa R, Stoute JA, Gittens RA, Spadafora C. PLoS One. 2016 Aug 18;11(8):e0161207. doi: 10.1371/journal.pone.0161207. eCollection 2016
  20. Medusamida A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids. Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ. Org Lett. 2016 Feb 5;18(3):352-5. doi: 10.1021/acs.orglett.5b03110
  21. Phytochemical composition, antiparasitic and α-glucosidase inhibition activities from Pelliciera rhizophorae. López D, Cherigo L, Spadafora C, Loza-Mejía MA, Martínez-Luis S. Chem Cent J. 2015 Sep 28;9(1):53
  22. Bastimolide A, a Potent Antimalarial Polyhydroxy Macrolide from the Marine Cyanobacterium Okeania hirsuta. Shao CL, Linington RG, Balunas MJ, Centeno A, Boudreau P, Zhang C, Engene N, Spadafora C, Mutka TS, Kyle DE, Gerwick L, Wang CY, Gerwick WH. J Org Chem. 2015 Aug 21;80(16):7849-55
  23. Malarial hemozoin: from target to tool. Lorena M. Coronado, Christoper T. Nadovich, Carmenza Spadafora. Biochim Biophys Acta. 2014 Jun;1840(6):2032-41 doi: 10.1016/j.bbagen.2014.02.009
  24. Chemical and bioactive natural products from Microthyriaceae sp., an endophytic fungus from a tropical grass. Celso Almeida, Humberto Ortega, Sarah Higginbotham, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Kursar Thomas A, William H. Gerwick and Luis Cubilla-Rios. Letters of Applied Microbiology 10 MAR 2014 03:29AM EST | DOI: 10.1111/lam.12245
  25. Sloth fur as a novel source of fungi with potent anti-parasitic, anti-cancer and anti-bacterial bioactivity Sarah Higginbotham, Weng Ruh Wong, Roger G. Linington, Carmenza Spadafora, Liliana Iturrado, A. Elizabeth Arnold. PLoS One 2014 Jan 15;9(1):e84549. doi: 10.1371/journal.pone.0084549
  26. Antimalarial activity and metabolic profiling by HS-SPME-GC-MS of Plinia cerrocampanensis leaf essential oil. Armando A Durant, Candelario Rodriguez, Liuris Herrera, Alejandro Almanza, Ana I Santana, Carmenza Spadafora and Mahabir P Gupta. Malaria J 01/2014; 13(1):18 doi:10.1186/1475-2875-13-18
  27. Microwave Exposure System for In Vitro and In Vivo Studies. Nadovich, C T, W D Jemison, J A Stoute, and C Spadafora. 2014. COMSOL Proceedings, Boston
  28. Bioactivity of fungal endophytes as a function of endophyte taxonomy and the taxonomy and distribution of their host plants. Higginbotham SJ, Arnold AE, Ibañez A, Spadafora C, Coley PD, Kursar, TA (2013). PLoS ONE 8(9): e73192. doi:10.1371/journal.pone.0073192
  29. Randomized, Double-Blinded, Phase 2 Trial of WR 279,396 (Paromomycin and Gentamicin) for Cutaneous Leishmaniasis in Panama. Sosa N, Capitán Z, Nieto J, Nieto M, Calzada J, Paz H, Spadafora C, Kreishman-Deitrick M, Kopydlowski K, Ullman D, McCarthy WF, Ransom J, Berman J, Scott C, Grogl M. Am J Trop Med Hyg. 2013 Sep;89(3):557-63. doi: 10.4269/ajtmh.12-0736.
  30. Separation of Plasmodium falciparum Late Stage-infected Erythrocytes by Magnetic Means. Coronado, L. M., Tayler, N. M., Correa, , Giovani, R. M., Spadafora, C. J. Vis. Exp. (73), e50342, doi:10.3791/50342 (2013)
  31. Antitrypanosomal Alkaloids from the marine bacterium Bacillus pumilu. Sergio Martínez-Luis, José Félix Gómez, Carmenza Spadafora, Héctor M. Guzmán, Marcelino Gutiérrez, Molecules, 2012 Sep 18;17(9):11146-55.
  32. Coibacins A-D, Antileishmanial Marine Cyanobacterial Polyketides with Intriguing Biosynthetic Origins. Balunas MJ, Grosso MF, Villa FA, Engene N, McPhail KL, Tidgewell K, Pineda LM, Gerwick L, Spadafora C, Kyle DE, Gerwick WH. Org Lett. 2012 Aug 3;14(15):3878-3881
  33. Coibanoles, a new class of meroterpenoids produced by Pycnoporus sanguineus. Eunice Molinar, Nivia Rios, Carmenza Spadafora, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios Tetrahedron Letters Volume 53, Issue 8, 22 February 2012, Pages 919–922
  34. Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Martínez-Luis S, Cherigo L, Arnold E, Spadafora C, Gerwick WH, Cubilla-Rios L. Natural product communications. 02/2012; 7(2):165-8.
  35. Evaluation of phytotoxic, cytotoxic and antiparasitic in vitro activities of Borreria verticillata, a weed of Panamanian coffee crops. L Cherigo, J Lezcano, C Spadafora, Sergio Martínez-Luis. Bioscience Research, 2012 9(2):82-86
  36. Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp. nov. Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH. J Nat Prod. 2012 Jan 27;75(1):60-6
  37. Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. Martínez-Luis S, Cherigo L, Higginbotham S, Arnold E, Spadafora C, Ibañez A, Gerwick WH, Cubilla-Rios L. Int Microbiol. 2011 Jun;14(2):95-102.
  38. Chemical constituents from the new endophytic fungus Mycosphaerella nov. and their anti-parasitic activity. Moreno, E., Varughese, T., Spadafora, C., Arnold, AE, Coley, PD, Kursar, TA, Gerwick, WH and Cubilla-Rios, L. Natural Product Communications, (2011) Vol. 6(6):835-840
  39. Plasmodium falciparum field isolates use complement receptor 1 (CR1) as a receptor for invasion of erythrocytes. Awandare GA, Spadafora C, Moch JK, Dutta S, Haynes JD, Stoute JA. Mol Biochem Parasitol. (2011) 177(1):57-60
  40. Comparison of the in vitro invasive capabilities of Plasmodium falciparum 7G8 schizonts isolated by Percoll gradient or using magnetic based separation.Spadafora, C., Gerena, L. and Kopydlowski, KM. (2011) Malaria Journal 2011, 10:96 (18 April 2011)
  41. Cytotoxic Veraguamides, Alkynyl Bromide-containing cyclic Depsipeptides from the marine Cyanobacterium cf. Osciallatoria margaritifera. Emily Mevers,Wei-Ting Liu, Niclas Engene, Hosein Mohimani, Tara Byrum, Pavel A. Pevzner, Pieter C. Dorrestein, Carmenza Spadafora, and William H. Gerwick. (2011) J Nat Prod. (2011) 74(5):928-36.
  42. Automated Synchronization of falciparum using a Temperature Cycling Incubator (TCI). Alejandro Almanza, A., Coronado, L., Tayler, N., Herrera, L. and Spadafora, C. Curr Trends Biotech Pharmacol (2011) Vol 5 (2):1130-133
  43. Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum. Spadafora, C., Awandare, G., Kopydlowski, K., Czege, J,, Moch, JK., Finberg, RW, Tsokos, G., Stoute, JA. (2010) PLoS Pathog Jun 17;6(6):e1000968
  44. In vitro and in vivo experimental models in drug screening and development for Chagas disease. Romanha AJ, Castro SL, Soeiro Mde N, Lannes-Vieira J, Ribeiro I, Talvani A, Bourdin B, Blum B, Olivieri B, Zani C, Spadafora C,, Chiari E, Chatelain E, Chaves G, Calzada JE, Bustamante JM, Freitas-Junior LH, Romero LI, Bahia MT, Lotrowska M, Soares M, Andrade SG, Armstrong T, Degrave W, Andrade Zde A.. Memórias do Instituto Oswaldo Cruz (2010) 105(2): 233-238.
  45. Additional anti-leishmanial constituents of the Panamanian Endophytic fungus Edenia sp. Martínez-Luis S; Cherigo, L; Spadafora, C;, Gerwick, WH.; and Cubillas-Rios, L Latinoamer. Quím. (2009) 37, (2), 104-114.
  46. Two Casein Kinase 1 isoforms are differentially expressed in the protozoan parasite Trypanosoma cruzi. Spadafora, C., Repetto, Y., Torres, C., Pino, L., Robello, C., Espinoza, I., Galanti, N., Morello, A., Gamarro, F., and Castanys, S. Molecular and Biochemical Parasitology (2002) 124/1-2:23-36.