His thesis on suicidal signals carried by Extracellular Vesicles of Plasmodium falciparum resulted in three important publications:
Extracellular vesicles could carry an evolutionary footprint in interkingdom communication. Ricardo Correa, Zuleima Caballero, Luis Fernando De León and Carmenza Spadafora. Frontiers in Cellular and Infection Microbiology. 03 March 2020 | https://doi.org/10.3389/fcimb.2020.00076
Extracellular vesicles carrying lactate dehydrogenase induce suicide in increased population density of Plasmodium falciparumin vitro. Ricardo Correa M, Lorena M Coronado, Zuleima Caballero, Paula Faral, Carlos Robello and Carmenza Spadafora. Scientific Reports 9, Article number: 5042 (2019
Volatile organic compounds associated with Plasmodium falciparum infection in vitro. Ricardo Correa, Lorena M. Coronado, Anette C. Garrido, Armando A. Durant-Archibold and Carmenza Spadafora. Parasites and Vectors. 2017 May 2;10(1):215
A summary of these findings was presented in the recent conference of the American Society of Tropical Medicine and Hygiene in Washington, D.C. Big congratulations!
Dr. Hyan-Ju Park, Professor at the School of Pharmacy of Sungkyunkwan University, in South Korea, spent some months with us sharing her expertise in medicinal chemistry, which was very valuable to our group of bioassays in parasites of tropical diseases and cancer. Some of the best molecules that we have published together with our collaborators were analyzed with her and new ideas for progressing analogs of those natural products were discussed. This is headed to be an important Panama-South Korea collaboration in the area of drug discovery. This exchange from visiting Prof. Park adds to the similar ongoing work established some years ago between our group and the Ocean University of Qindao, China.
The equipment comprises Optical Tweezers, a nano force measurement device and a CellXtor. Optical Tweezers are able to hold nanoparticles with the use of laser beams. Their generated force fields, are able to exert a pressure on the particles, and placed in opposite directions, the two lasers trap and manipulate their target in between the fields. This allows, among other things, the application of strain or stress forces that can give exact information on the physical properties of a nanoparticle. The CellXtor can mark single cells or particles of interest and collect them, one or many at a time, to deposit them into a dish well for further use. One of the first projects to utilize the new technology will use the Optical tweezers to measure the elasticity of red blood cells.
This equipment was acquired through competitive funding from the National Secretariat of Science, Innovation and Technology of Panama. It will be available for users from any institution that want to conduct studies using this technology.
We are delighted to inform that Dra. Carmenza Spadafora has been invited as Editorial Board Member of prestigious Journal Scientific Reports- Nature Publisher Journal with impact factor: 4.8 It is very great honor for her and all of us. pic.twitter.com/qdmb5nucQ8
The GEF 7 program for Panama has accepted the proposal presented by the Group of Drug Discovery and Bioprospection of INDICASAT with University of Panama collaboration. The project will make use of the benefits that native microbes could have related to their agricultural and medical potentials. INDICASAT AIP has almost 20 years of experience running a very succesful academic and conservation program with Funding from NIH, USDA, NSF, GEF, SENACYT and more recently, the Ministry of Environment through their Fund for Wildlife, Biodiversity and Water.
The launching of the project, which should be ready for implementation around April or May 2020, gathered stakeholders from INDICASAT AIP, University of Panama, the United Nations Development Program, Ministry of Finance of Panama, Ministry of Environment of Panama and the Director of the National Park “La Amistad”, spreading between Panama and Costa Rica, where some of the activity related to biological control will take place. The program will strengthen the concept of sustainability of biodiversity through the development of useful products to society out of scientific discovery.